Research progress in the relationship between iron deficiency and tic disorder

Tic disorder is a common neurodevelopmental disorder disease in children， with a high prevalence and different clinical manifestations among individuals. It is frequently complicated with other neuropsychiatric diseases， which brings significant burden to psychological and physical health of patients. At present， the etiology of tic disorder remains unclear， which is probably associated with genetic， immune， environmental and psychological factors， etc. The pathological mechanism involves cortico-striatum-thalamic-cortical pathway disorders and neurotransmitter abnormalities. Iron has an extremely important biological function in the developmental process of nervous system. Studies have found that iron deficiency may lead to brain development disorder and dopaminergic dysfunction， thereby causing the incidence and progression of tic disorder. Improving the nutritional status of iron through iron supplementation may become a new idea for the prevention and treatment of children with tic disorder.