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A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia
- Source :
- Animal Models and Experimental Medicine, Vol 7, Iss 3, Pp 367-376 (2024)
- Publication Year :
- 2024
- Publisher :
- Wiley, 2024.
-
Abstract
- Abstract Background Severe trauma is associated with systemic inflammation and organ dysfunction. Preclinical rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human trauma. The aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic injury. Methods Male Sprague–Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock (LCHS), multicompartmental polytrauma (PT) (unilateral lung contusion, hemorrhagic shock, cecectomy, bifemoral pseudofracture), or naïve controls. Weight, plasma toll‐like receptor 4 (TLR4), hemoglobin, spleen to body weight ratio, bone marrow (BM) erythroid progenitor (CFU‐GEMM, BFU‐E, and CFU‐E) growth, plasma granulocyte colony‐stimulating factor (G‐CSF) and right lung histologic injury were assessed on day 7, with significance defined as p values
- Subjects :
- anemia
inflammation
polytrauma
pseudofracture
shock
Medicine (General)
R5-920
Subjects
Details
- Language :
- English
- ISSN :
- 25762095
- Volume :
- 7
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Animal Models and Experimental Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.89b941a61a2944e1adf0e4f2fda1475d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/ame2.12447