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Pan‐cancer population pharmacokinetics and exposure‐safety and ‐efficacy analyses of atezolizumab in patients with high tumor mutational burden

Authors :
Colby S. Shemesh
Phyllis Chan
Fatema A. Legrand
David S. Shames
Meghna Das Thakur
Jane Shi
Lorna Bailey
Shweta Vadhavkar
Xian He
Wei Zhang
René Bruno
Source :
Pharmacology Research & Perspectives, Vol 8, Iss 6, Pp n/a-n/a (2020)
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

Abstract We retrospectively investigated the pharmacokinetics and exposure‐efficacy/safety relationships of single‐agent atezolizumab based on tissue tumor mutational burden (tTMB) status (high vs low [≥16 vs

Details

Language :
English
ISSN :
20521707
Volume :
8
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Pharmacology Research & Perspectives
Publication Type :
Academic Journal
Accession number :
edsdoj.89b5559af7e4b42a15cf0069035da3c
Document Type :
article
Full Text :
https://doi.org/10.1002/prp2.685