Back to Search
Start Over
Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland
- Source :
- Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group, 2021.
-
Abstract
- Abstract Hypothalamic–pituitary–adrenal (HPA) axis dysregulation has been commonly reported in major depressive disorder (MDD), but with considerable heterogeneity of results; potentially due to the predominant use of acute measures of an inherently variable/phasic system. Chronic longer-term measures of HPA-axis activity have yet to be systematically examined in MDD, particularly in relation to brain phenotypes, and in the context of early-life/contemporaneous stress. Here, we utilise a temporally stable measure of cumulative HPA-axis function (hair glucocorticoids) to investigate associations between cortisol, cortisone and total glucocorticoids with concurrent measures of (i) lifetime-MDD case/control status and current symptom severity, (ii) early/current-life stress and (iii) structural neuroimaging phenotypes, in N = 993 individuals from Generation Scotland (mean age = 59.1 yrs). Increased levels of hair cortisol were significantly associated with reduced global and lobar brain volumes with reductions in the frontal, temporal and cingulate regions (β range = −0.057 to −0.104, all P FDR
- Subjects :
- Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 21583188
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Translational Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.89b054256ca14047ae3a738743e18a0d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41398-021-01644-9