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Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study

Authors :
Ian López-Cruz
Ana Esparcia
Manuel Madrazo
Juan Alberola
José María Eiros
Arturo Artero
Source :
Heliyon, Vol 8, Iss 10, Pp e11131- (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

Aim: This study aimed to evaluate clinically significant sex differences that could have an effect on the choice of treatment and outcomes of urinary tract infection (UTI) in aged 80 and over hospitalized patients with community-acquired UTI. Methods: This was a prospective study of 161 patients aged 80 and over admitted to hospital with community-acquired UTI. Epidemiological, clinical, laboratory and microbiologic variables were compared between both sexes. Multivariate analysis was performed using logistic regression to determine the variables independently associated with sex. Results: In a population of 91 (56.52%) women and 70 (43.48%) men, aged 80 and over, we found that women were more likely to have cognitive impairment (p = 0.035) and less likely to have chronic obstructive pulmonary disease (COPD) (p = 0.006) and indwelling urinary catheter (p < 0.001) than men. Levels of creatinine were higher in men than in women (p = 0.008). Septic shock at presentation was more frequent in the male group (p = 0.043). Men had a higher rate of polymicrobial infection (p = 0.035) and Pseudomonas aeruginosa infection (p = 0.003). Factors independently associated with sex by multivariate analysis were septic shock, cognitive impairment, COPD and indwelling urinary catheter. Conclusion: Men aged 80 and over with community-acquired UTI had more septic shock at admission to hospital and higher rates of indwelling urinary catheter, while women had more cognitive impairment. There were no differences in outcomes between sexes.

Details

Language :
English
ISSN :
24058440
Volume :
8
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.89994f7dca8d4167adf9450a42b0869e
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2022.e11131