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Targeting transcription in heart failure via CDK7/12/13 inhibition

Authors :
Austin Hsu
Qiming Duan
Daniel S. Day
Xin Luo
Sarah McMahon
Yu Huang
Zachary B. Feldman
Zhen Jiang
Tinghu Zhang
Yanke Liang
Michael Alexanian
Arun Padmanabhan
Jonathan D. Brown
Charles Y. Lin
Nathanael S. Gray
Richard A. Young
Benoit G. Bruneau
Saptarsi M. Haldar
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

In this study, Hsu et al. show that inhibition of CDK7/12/13 attenuates maladaptive transcriptional activation in cultured cardiomyocytes and a mouse model of heart failure, suggesting that targeting the transcription machinery might be a therapeutic approach to treat heart failure with reduced ejection fraction.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.88ec7013f71b476595a136b3ce75ccd1
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31541-8