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Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

Authors :
Joseph C. Mudd
Kathleen Busman-Sahay
Sarah R. DiNapoli
Stephen Lai
Virginia Sheik
Andrea Lisco
Claire Deleage
Brian Richardson
David J. Palesch
Mirko Paiardini
Mark Cameron
Irini Sereti
R. Keith Reeves
Jacob D. Estes
Jason M. Brenchley
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Innate lymphoid cells (ILCs) have been shown to be depleted during HIV-1 infection. Here the authors show that ILC loss is associated with CD4 depletion and gastrointestinal damage in a primate model of SIV infection.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.88eb33c0a42b444ea1e49cf60a21484e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-05528-3