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Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.

Authors :
Danni Ramduth
Cheryl L Day
Christina F Thobakgale
Nompumelelo P Mkhwanazi
Chantal de Pierres
Sharon Reddy
Mary van der Stok
Zenele Mncube
Kriebashne Nair
Eshia S Moodley
Daniel E Kaufmann
Hendrik Streeck
Hoosen M Coovadia
Photini Kiepiela
Philip J R Goulder
Bruce D Walker
Source :
PLoS ONE, Vol 4, Iss 4, p e5013 (2009)
Publication Year :
2009
Publisher :
Public Library of Science (PLoS), 2009.

Abstract

A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This association has not been investigated in terms of Gag-specific CD4+ T cell responses, nor have clade C HIV-1-specific CD4+ T cell epitopes, likely a vital component of an effective global HIV-1 vaccine, been identified.Intracellular cytokine staining was conducted on 373 subjects with chronic, untreated clade C infection to assess interferon-gamma (IFN-gamma) responses by CD4+ T cells to pooled Gag peptides and to determine their association with viral load and CD4 count. Gag-specific IFN-gamma-producing CD4+ T cell responses were detected in 261/373 (70%) subjects, with the Gag responders having a significantly lower viral load and higher CD4 count than those with no detectable Gag response (p

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
4
Issue :
4
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.88e71953b84f48aebb816035d8099c
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0005013