Genetic Susceptibility for Low Testosterone in Men and Its Implications in Biology and Screening: Data from the UK Biobank

Background: Despite strong evidence of heritability, few studies have attempted to unveil the genetic underpinnings of testosterone levels. Objective: To identify testosterone-associated loci in a large study and assess their biological and clinical implications. Design, setting, and participants: The participants were men from the UK Biobank. A two-stage genome-wide association study (GWAS) was first used to identify/validate loci for low testosterone (LowT,