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Tissue-specific 5-hydroxymethylcytosine landscape of the human genome

Authors :
Bo He
Chao Zhang
Xiaoxue Zhang
Yu Fan
Hu Zeng
Jun’e Liu
Haowei Meng
Dongsheng Bai
Jinying Peng
Qian Zhang
Wei Tao
Chengqi Yi
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-specific patterns.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.881fb687b21471b850c6a144a8cec64
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-24425-w