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Microfluidic active loading of single cells enables analysis of complex clinical specimens

Authors :
Nicholas L. Calistri
Robert J. Kimmerling
Seth W. Malinowski
Mehdi Touat
Mark M. Stevens
Selim Olcum
Keith L. Ligon
Scott R. Manalis
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Single-cell detection methods are limited by the trade-off between flow rate and measurement precision. Here the authors introduce active loading, an optically triggered microfluidic system to concentrate diluted cell samples, which reduces clogging and decreases processing time in single-cell assays.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.87b9574143a84e82ab152a42f9a0ce1c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-07283-x