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Maternal BPAF exposure impaired synaptic development and caused behavior abnormality in offspring

Authors :
Xiaorong Wu
Shiqi Li
Yangyue Ni
Caoyan Qi
Shengjun Bai
Qiaoqiao Xu
Yun Fan
Xuan Ma
Chuncheng Lu
Guizhen Du
Zhipeng Xu
Yufeng Qin
Source :
Ecotoxicology and Environmental Safety, Vol 256, Iss , Pp 114859- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Bisphenol A (BPA) has been widely restricted, leading to a significant increase in the production of bisphenol AF (BPAF), one of the most common bisphenol analogs use as a substitute for BPA. However, there is limit evidence on the neurotoxicity of BPAF, especially the potential effects of maternal exposed to BPAF on offspring. A maternal BPAF exposure model was used to evaluate its effects on long-term neurobehaviors in offspring. We found that maternal BPAF exposure resulted in immune disorders, characterized by abnormal CD4+T cell subsets, and their offspring exhibited anxiety- and depression-like behaviors, as well as impairments in learning-memory, sociability and social novelty. Further, brain bulk RNA-sequencing (RNA-seq) and hippocampus single-nucleus RNA-sequencing (snRNA-seq) of offspring showed that differentially expressed genes (DEGs) were enriched in pathways related to synaptic and neurodevelopment. Synaptic ultra-structure of offspring was damaged after maternal BPAF exposure. In conclusion, maternal BPAF exposure induced behavior abnormality in adult offspring, together with synaptic and neurodevelopment defects, which might be related to maternal immune dysfunction. Our results provide a comprehensive insight into the neurotoxicity mechanism of maternal BPAF exposure during gestation. Given the increasing and ubiquitous exposure to BPAF, especially during sensitive periods of growth and development, the safety of BPAF requires urgent attention.

Details

Language :
English
ISSN :
01476513
Volume :
256
Issue :
114859-
Database :
Directory of Open Access Journals
Journal :
Ecotoxicology and Environmental Safety
Publication Type :
Academic Journal
Accession number :
edsdoj.8741d4e89f5940a7a554658095aa060d
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ecoenv.2023.114859