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Summary of Guidelines for Managing Histoplasmosis among People Living with HIV

Authors :
Freddy Perez
Diego H. Caceres
Nathan Ford
Giovanni Ravasi
Beatriz L. Gomez
Alessandro C. Pasqualotto
Paul Hine
Antoine A. Adenis
Mathieu Nacher
Tom Chiller
John Baddley
for the Guideline Development Group for diagnosing and managing disseminated histoplasmosis among people living with HIV
Source :
Journal of Fungi, Vol 7, Iss 2, p 134 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population. In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was published. This document recommends (1) detection of circulating Histoplasma antigens as the recommended laboratory assay to diagnose histoplasmosis among PLHIV; (2) the use of liposomal amphotericin for induction therapy in severe or moderately severe disease, followed by a maintenance therapy with itraconazole for 12 months; a shorter maintenance therapy could be considered if the patient is clinically stable and if immune status has improved; (3) antiretroviral therapy initiation as soon as possible among patients with histoplasmosis without involvement of central nervous system; and (4) that for the treatment of co-infection with histoplasmosis and tuberculosis (TB), treatment of TB should be initiated according to the World Health Organization treatment guidelines. Appropriate health education of providers, supportive supervision, and policy guidance for the care of PLHIV are required.

Details

Language :
English
ISSN :
2309608X and 87374706
Volume :
7
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Journal of Fungi
Publication Type :
Academic Journal
Accession number :
edsdoj.873747063fef4ca290332862b2bff9df
Document Type :
article
Full Text :
https://doi.org/10.3390/jof7020134