Sex discrepancies in COPD patients and burden of the disease in females: a nationwide study in Greece (Greek Obstructive Lung Disease Epidemiology and health ecoNomics: GOLDEN study)

Andriana I Papaioannou,1,2 Eleni Bania,2 Evangelos C Alexopoulos,3 Eirini Mitsiki,4 Foteini Malli,2 Konstantinos I Gourgoulianis2 13rd Respiratory Medicine Department, Sismanoglio General Hospital, Marousi, Athens, Greece; 2Respiratory Medicine Department, University of Thessaly Medical School University Hospital of Larissa, Larissa, Greece; 3Occupational Health Department, Onassis Cardiac Surgery Center, Athens, Greece; 4Medical Department, Novartis Hellas, Athens, Greece Background: The prevalence of chronic obstructive pulmonary disease (COPD) in females appears to be increasing. Recent studies have revealed that the percentage of women with COPD in Greece is approximately 12.5%. Aims: To evaluate the burden of COPD among males and females in Greece through a nationwide cross-sectional survey and to explore sex differences regarding functional characteristics and exacerbation frequency. Methods: Data collection was completed in a 6-month period. The present study followed a nationwide sampling approach of respiratory medicine physicians. The sampling approach included three steps: 1) estimation of expected incidence and prevalence of COPD cases in each prefecture of Greece and in total; 2) estimation of expected incidence of COPD cases per physician in each prefecture; and 3) creation of a frame of three different sampling zones. Following this sampling, data were provided by 199 respiratory physicians. Results: The participating physicians provided data from 6,125 COPD patients. Female patients represented 28.7% of the study participants. Female COPD patients were, on average, 5 years younger than male COPD patients. Never smokers accounted for 9.4% within female patients, compared to 2.7% of males (P