The correlation of two bone turnover markers with bone mineral density: a population-based cross-sectional study

Abstract Objective Exploring the correlation between bone turnover marks (BTMs) with lumbar BMD in middle-aged populations. Methods The cross-sectional analysis fetched data came from NHANES. The level of serum bone alkaline phosphatase (sBAP) and urinary N-telopeptide (uNTx) were regarded as representative of bone turnover. Lumbar BMD was the outcome of the study. Multivariable linear regression models were utilized to detect the correlation of sBAP and uNTx with Lumbar BMD. Results The level of sBAP and uNTx was negatively correlated with lumbar BMD in every multivariable linear regression. For sBAP, this inverse correlation was stable in both men and women (P