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Histoplasmosis in Solid Organ Transplantation

Authors :
Nicolas Barros
L. Joseph Wheat
Source :
Journal of Fungi, Vol 10, Iss 2, p 124 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Histoplasma capsulatum, the etiological agent for histoplasmosis, is a dimorphic fungus that grows as a mold in the environment and as a yeast in human tissues. It has a broad global distribution with shifting epidemiology during recent decades. While in immunocompetent individuals infection is usually self-resolving, solid organ transplant recipients are at increased risk of symptomatic disease with dissemination to extrapulmonary tissue. Diagnosis of histoplasmosis relies on direct observation of the pathogen (histopathology, cytopathology, and culture) or detection of antigens, antibodies, or nucleic acids. All transplant recipients with histoplasmosis warrant therapy, though the agent of choice and duration of therapy depends on the severity of disease. In the present article, we describe the pathogenesis, epidemiology, clinical manifestations and management of histoplasmosis in solid organ transplant recipients.

Details

Language :
English
ISSN :
2309608X
Volume :
10
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Journal of Fungi
Publication Type :
Academic Journal
Accession number :
edsdoj.865018c1484a470b848bb6c42dc5f985
Document Type :
article
Full Text :
https://doi.org/10.3390/jof10020124