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cVEMP correlated with imbalance in a mouse model of vestibular disorder
- Source :
- Environmental Health and Preventive Medicine, Vol 24, Iss 1, Pp 1-10 (2019)
- Publication Year :
- 2019
- Publisher :
- Komiyama Printing Co. Ltd, 2019.
-
Abstract
- Abstract Background Cervical vestibular evoked myogenic potential (cVEMP) testing is a strong tool that enables objective determination of balance functions in humans. However, it remains unknown whether cVEMP correctly expresses vestibular disorder in mice. Objective In this study, correlations of cVEMP with scores for balance-related behavior tests including rotarod, beam, and air-righting reflex tests were determined in ICR mice with vestibular disorder induced by 3,3′-iminodipropiontrile (IDPN) as a mouse model of vestibular disorder. Methods Male ICR mice at 4 weeks of age were orally administered IDPN in saline (28 mmol/kg body weight) once. Rotarod, beam crossing, and air-righting reflex tests were performed before and 3–4 days after oral exposure one time to IDPN to determine balance functions. The saccule and utricles were labeled with fluorescein phalloidin. cVEMP measurements were performed for mice in the control and IDPN groups. Finally, the correlations between the scores of behavior tests and the amplitude or latency of cVEMP were determined with Spearman’s rank correlation coefficient. Two-tailed Student’s t test and Welch’s t test were used to determine a significant difference between the two groups. A difference with p
- Subjects :
- cVEMP
Balance
Vestibule
Hair cells
IDPN
Public aspects of medicine
RA1-1270
Subjects
Details
- Language :
- English
- ISSN :
- 1342078X and 13474715
- Volume :
- 24
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Environmental Health and Preventive Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.85e37b9df3741258a9486ebecae7c3f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12199-019-0794-8