Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy

Authors :: Noriaki Miyanaga
Hideaki Takagi
Tomofumi Uto
Tomohiro Fukaya
Junta Nasu
Takehito Fukui
Yotaro Nishikawa
Tim Sparwasser
Narantsog Choijookhuu
Yoshitaka Hishikawa
Takeshi Nakamura
Tetsuya Tono
Katsuaki Sato
Source :: Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: Noriaki Miyanaga and Hideaki Takagi et al. identify an essential role for migratory dendritic cells in mediating immunotherapy treatment against allergies in mice. They show that submandibular lymph node dendritic cells induce regulatory T cells, and their absence abrogates the effectiveness of immunotherapy treatment.

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