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An In-Depth Review of the Benefits of Antibiotic Use in the Treatment of Borreliosis in Pregnancy

Authors :
Michael J. Cook
David Moynan
Gordana Avramovic
John S. Lambert
Source :
Applied Microbiology, Vol 3, Iss 2, Pp 312-321 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Evidence of congenital transmission of Lyme disease from mother to fetus has been investigated since the 1980s. This study reports the results of a retrospective analysis of 31 studies described in 27 papers published in a 2018 review article. Analysis of these identified statistically probable transmission in 13 (42%) of the 31 studies and possible transmission in 2 (6%). Most studies included mothers who had been treated with antimicrobials. When no antimicrobials were used, 74% of the pregnancies had adverse outcomes. When oral antimicrobials were used, 29% of pregnancies had adverse outcomes. When intravenous (IV) antimicrobials were used, adverse outcomes dropped to 12% of the pregnancies. This is a six-fold reduction in risk compared with no antimicrobial treatment. Some studies did not define whether oral or IV antimicrobials were used. When these results were included, adverse outcomes were 30 times higher for untreated mothers. Adverse outcomes included deaths, heart anomalies, and preterm births.

Details

Language :
English
ISSN :
26738007
Volume :
3
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Applied Microbiology
Publication Type :
Academic Journal
Accession number :
edsdoj.8563175c514a4f91b168e1a4f0101b2f
Document Type :
article
Full Text :
https://doi.org/10.3390/applmicrobiol3020022