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Genotoxic potential of selected medicinal plant extracts in human whole blood cultures

Authors :
Karina Harutyunyan
Karine Balayan
Gohar Tadevosyan
Manush Hayrapetyan
Ruzanna Musayelyan
Ruzanna Grigoryan
Lusine Khondkaryan
Natalya Sarkisyan
Nelly Babayan
Source :
Journal of HerbMed Pharmacology, Vol 8, Iss 2, Pp 160-162 (2019)
Publication Year :
2019
Publisher :
Shahrekord University of Medical Sciences, 2019.

Abstract

Introduction: Many plant-derived products despite wide usage are not scientifically evaluated for their safety and efficacy. Therefore, in the present study, we aimed to evaluate the cytotoxic and genotoxic activities of Polygonum aviculare L., Equisetum arvense L., Plantago lanceolata L. and Artemisia absinthium L. ethanolic extracts in human white blood cells. Methods: Cell viability was assayed by trypan blue exclusion method, while the genotoxicity was tested by cytokinesis-block micronucleus (CBMN) assay upon cells stimulation with noncytotoxic concentrations of the plant extracts. Results: None of the plant extracts showed high cytotoxic activity. At the same time, only extract of P. lanceolata did not present any mutagenic activity, while E. arvense, P. aviculare and A. absinthium were clearly genotoxic. Conclusion: Caution is advice in the case of long-term use of E. arvense, P. aviculare and A. absinthium herbal medicines by population.

Details

Language :
English
ISSN :
23455004
Volume :
8
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Journal of HerbMed Pharmacology
Publication Type :
Academic Journal
Accession number :
edsdoj.85630f8f509749d6913beb751aef1d90
Document Type :
article
Full Text :
https://doi.org/10.15171/jhp.2019.25