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Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population

Authors :
Hui Wei
Ying Wang
Chunlin Zhou
Dong Lin
Bingcheng Liu
Kaiqi Liu
Shaowei Qiu
Benfa Gong
Yan Li
Guangji Zhang
Shuning Wei
Xiaoyuan Gong
Yuntao Liu
Xingli Zhao
Runxia Gu
Yingchang Mi
Jianxiang Wang
Source :
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-4 (2018)
Publication Year :
2018
Publisher :
BMC, 2018.

Abstract

Abstract Racial and ethnic disparities in malignancies attract extensive attention. To investigate whether there are racial and ethnic disparities in genetic alteration between Caucasian and Eastern Asian population, data from several prospective AML trials were retrospectively analyzed in this study. We found that there were more patients with core binding factor (CBF) leukemia in Eastern Asian cohorts and there were different CBF leukemia constitutions between them. The ratios of CBF leukemia are 27.7, 22.1, 21.1, and 23.4%, respectively, in our (ChiCTR-TRC-10001202), another Chinese, Korean, and Japanese Eastern Asian cohorts, which are significantly higher than those in ECOG1900, MRC AML15, UK NCRI AML17, HOVON/SAKK AML-42, and German AML2003 (15.5, 12.5, 9.3, 10.2, and 12%, respectively). And CBFbeta-MYH11 occurred more prevalently in HOVON/SAKK AML- 42 and ECOG1900 trials (50.0 and 54.3% of CBF leukemia, respectively) than in Chinese and Japanese trials (20.1 and 20.8%, respectively). The proportion of FLT3-ITD mutation is 11.2% in our cohort, which is lower than that in MRC AML15 and UK NCRI AML17 (24.6 and 17.9%, respectively). Even after excluding the age bias, there are still different incidence rates of mutation between Caucasian and Eastern Asian population. These data suggest that there are racial and ethnic disparities in genetic alteration between Caucasian and Eastern Asian population.

Details

Language :
English
ISSN :
17568722
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Hematology & Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.855bf9f079a0476cb329db228faf5912
Document Type :
article
Full Text :
https://doi.org/10.1186/s13045-018-0566-8