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Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives
- Source :
- Molecules, Vol 13, Iss 1, Pp 69-77 (2008)
- Publication Year :
- 2008
- Publisher :
- MDPI AG, 2008.
-
Abstract
- The aim of this study was to identify new compounds active againstPlasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds weresynthesized and evaluated for antimalarial activity. Eight of them showed an IC50 less than 1 μMagainst the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 μM) and goodselectivity (SI=10.35), thereby becoming a new lead-compound.
- Subjects :
- Quinoxaline
N-oxides
malaria
antiplasmodial
P. falciparum.
Organic chemistry
QD241-441
Subjects
Details
- Language :
- English
- ISSN :
- 13010069 and 14203049
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.84eca9e233f149df82485969c6dea4b0
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/molecules13010069