A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Authors :: Laura-Oana Albulescu
Chunfang Xie
Stuart Ainsworth
Jaffer Alsolaiss
Edouard Crittenden
Charlotte A. Dawson
Rowan Softley
Keirah E. Bartlett
Robert A. Harrison
Jeroen Kool
Nicholas R. Casewell
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-inhibiting repurposed drugs provides broad protection in experimental animals against the lethal effects of snakebites from multiple snake species.

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