Back to Search Start Over

Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role

Authors :
Xiaoyun Cheng
Shuhan Jiang
Boyu Pan
Wei Xie
Jie Meng
Source :
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-19 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Idiopathic pulmonary fibrosis (IPF) is considered an age-related disease. Age-related changes, along with other factors such as obesity, hormonal imbalances, and various metabolic disorders, lead to ectopic fat deposition (EFD). This accumulation of fat outside of its normal storage sites is associated with detrimental effects such as lipotoxicity, oxidative stress, inflammation, and insulin resistance. This narrative review provides an overview of the connection between ectopic and visceral fat deposition in aging, obesity, and IPF. It also elucidates the mechanism by which ectopic fat deposition in the airways and lungs, pericardium, skeletal muscles, and pancreas contributes to lung injury and fibrosis in patients with IPF, directly or indirectly. Moreover, the review discusses the impact of EFD on the severity of the disease, quality of life, presence of comorbidities, and overall prognosis in IPF patients. The review provides detailed information on recent research regarding representative lipid-lowering drugs, hypoglycemic drugs, and lipid-targeting drugs in animal experiments and clinical studies. This may offer new therapeutic directions for patients with IPF.

Details

Language :
English
ISSN :
1476511X
Volume :
22
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Lipids in Health and Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.8454421f870646c89c38d1aefaf57db1
Document Type :
article
Full Text :
https://doi.org/10.1186/s12944-023-01964-3