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Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- Polarisation of epithelial cells causes lumen formation, which is mediated by apical membrane initiation site (AMIS) and FIP5, but how this is regulated is unclear. Here, the authors identify cingulin as a FIP-5 interacting protein, recruiting the Rac1-WAVE/Scar complex to the AMIS and branched actin formation.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.845014529cdd4857ab83d3e6c1694918
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms12426