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Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1 and sE-Selectin) in Healthy School Aged Children and Adults
- Source :
- Acta Medica, Vol 43, Iss 3, Pp 103-106 (2000)
- Publication Year :
- 2000
- Publisher :
- Karolinum Press, 2000.
-
Abstract
- The aim of this study was to map normal levels of serum soluble isoforms of adhesion molecules in relation to age and sex in the group of school-aged children. sICAM-1, sVCAM-1 and sE-selectin were determined in the group of 158 normal children subdivided into two subgroups; 6-10 years (68 children, median age 8 years) and 11-15 years (90 children, median age 12 years) and in 70 normal adult blood donors (25 females and 45 males, median age 46 years). The levels of sICAM-1 and sE-selectin fell down significantly over the age range 6-15 years, while the level of sVCAM-1 was remained. Age-related normal ranges were established using correlation analysis and were expressed as the 5%-95% percentiles intervals: sICAM-1 206.8-486.8 ng/ml, sE-selectin 36.7-153.2 ng/ml in the group of 6-10 years old children, sICAM-1 184.1-354.0 ng/ml, sE-selectin 29.9-114.1 ng/ml in group of 11-15 years old children. The levels of sVCAM-1 were 359.6-822.0 ng/ml and were constant within the examined age interval from 6 to 15 years. The influence of sex was also assayed and it was not statistically significant in any age category tested. Normal ranges of sICAM-1 (60.2-218.4 ng/ml), sE-selectin (8.3-116.9 ng/ml) and sVCAM-1 (338.0-1148.0 ng/ml) were established for adult population of healthy blood donors using the same methods.
- Subjects :
- Children
Normal levels
sE-selectin
sICAM-1
sVCAM-1
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 18059694 and 12114286
- Volume :
- 43
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Medica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.841ec7f943e47a7b2de0853e3d69c4e
- Document Type :
- article
- Full Text :
- https://doi.org/10.14712/18059694.2019.121