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Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1 and sE-Selectin) in Healthy School Aged Children and Adults

Authors :
Ctirad Andrýs
Oldřich Pozler
Jan Krejsek
Václav Derner
Marcela Drahošová
Otakar Kopecký
Source :
Acta Medica, Vol 43, Iss 3, Pp 103-106 (2000)
Publication Year :
2000
Publisher :
Karolinum Press, 2000.

Abstract

The aim of this study was to map normal levels of serum soluble isoforms of adhesion molecules in relation to age and sex in the group of school-aged children. sICAM-1, sVCAM-1 and sE-selectin were determined in the group of 158 normal children subdivided into two subgroups; 6-10 years (68 children, median age 8 years) and 11-15 years (90 children, median age 12 years) and in 70 normal adult blood donors (25 females and 45 males, median age 46 years). The levels of sICAM-1 and sE-selectin fell down significantly over the age range 6-15 years, while the level of sVCAM-1 was remained. Age-related normal ranges were established using correlation analysis and were expressed as the 5%-95% percentiles intervals: sICAM-1 206.8-486.8 ng/ml, sE-selectin 36.7-153.2 ng/ml in the group of 6-10 years old children, sICAM-1 184.1-354.0 ng/ml, sE-selectin 29.9-114.1 ng/ml in group of 11-15 years old children. The levels of sVCAM-1 were 359.6-822.0 ng/ml and were constant within the examined age interval from 6 to 15 years. The influence of sex was also assayed and it was not statistically significant in any age category tested. Normal ranges of sICAM-1 (60.2-218.4 ng/ml), sE-selectin (8.3-116.9 ng/ml) and sVCAM-1 (338.0-1148.0 ng/ml) were established for adult population of healthy blood donors using the same methods.

Details

Language :
English
ISSN :
18059694 and 12114286
Volume :
43
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Acta Medica
Publication Type :
Academic Journal
Accession number :
edsdoj.841ec7f943e47a7b2de0853e3d69c4e
Document Type :
article
Full Text :
https://doi.org/10.14712/18059694.2019.121