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Primary Malignant Liver Tumors: eight-year experience in a Pediatric Hospital in Brazil. A cross-sectional study
- Source :
- Revista do Colégio Brasileiro de Cirurgiões, Vol 49 (2022)
- Publication Year :
- 2022
- Publisher :
- Colégio Brasileiro de Cirurgiões, 2022.
-
Abstract
- ABSTRACT Introduction: liver tumors are rare neoplasms in childhood (1-2%), and about 2/3 are malignant. Hepatoblastoma (HB) is the most frequent, followed by hepatocellular carcinoma (HCC). In both, the main treatment is surgical resection. Currently, chemotherapy and liver transplantation have improved outcomes. Objective: study of the epidemiological profile and evolution of liver cancer cases in a referral pediatric hospital. Methodology: a retrospective survey of medical records of patients aged up to 18 years with a diagnosis of primary malignant hepatic neoplasm between 2012 and 2020, carried out in the largest exclusively pediatric hospital in Brazil. Results: a total of 13 patients with malignant liver tumors (HB 12, HCC 1) were treated. Of the HB cases, 66,7% were male, with a mean age of 2 years and the main alteration in the palpable abdominal mass. Tumors involved an average of 3 liver segments, more in the right lobe (54%). Only one patient was treated with surgery without neoadjuvant therapy, another one underwent transplantation like the first treatment, and another 2 required liver transplantation as a rescue. The middle follow-up time of patients with HB was 39 months and only 1 case died due to febrile neutropenia. The 5-year overall and disease-free survival was 91.7% and 81.5%, respectively. Conclusion: Advanced staging at the time of diagnosis has always been a poor prognostic factor in patients with primary malignant liver tumors. However, the results and survival have improved with the advancement of chemotherapy, surgical technique, and liver transplantation.
Details
- Language :
- English, Spanish; Castilian, Portuguese
- ISSN :
- 18094546 and 01006991
- Volume :
- 49
- Database :
- Directory of Open Access Journals
- Journal :
- Revista do Colégio Brasileiro de Cirurgiões
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.841e3a125f064c3c836cb3945b81eaff
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/0100-6991e-20223273-en