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PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.841cd70bc974e82bf6c4f6bbe42719f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-11672-1