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Impact of discontinuation of contact precautions on surveillance- and whole genome sequencing-defined methicillin-resistant Staphylococcus aureus healthcare-associated infections
- Source :
- Antimicrobial Stewardship & Healthcare Epidemiology, Vol 4 (2024)
- Publication Year :
- 2024
- Publisher :
- Cambridge University Press, 2024.
-
Abstract
- Abstract Objective: Prior studies evaluating the impact of discontinuation of contact precautions (DcCP) on methicillin-resistant Staphylococcus aureus (MRSA) outcomes have characterized all healthcare-associated infections (HAIs) rather than those likely preventable by contact precautions. We aimed to analyze the impact of DcCP on the rate of MRSA HAI including transmission events identified through whole genome sequencing (WGS) surveillance. Design: Quasi experimental interrupted time series. Setting: Acute care medical center. Participants: Inpatients. Methods: The effect of DcCP (use of gowns and gloves) for encounters among patients with MRSA carriage was evaluated using time series analysis of MRSA HAI rates from January 2019 through December 2022, compared to WGS-defined attributable transmission events before and after DcCP in December 2020. Results: The MRSA HAI rate was 4.22/10,000 patient days before and 2.98/10,000 patient days after DcCP (incidence rate ratio [IRR] 0.71 [95% confidence interval 0.56–0.89]) with a significant immediate decrease (P = .001). There were 7 WGS-defined attributable transmission events before and 11 events after DcCP (incident rate ratio 0.90 [95% confidence interval 0.30–2.55]). Conclusions: DcCP did not result in an increase in MRSA HAI or, in WGS-defined attributable transmission events. Comprehensive analyses of the effect of transmission prevention measures should include outcomes specifically measuring transmission-associated HAI.
- Subjects :
- Infectious and parasitic diseases
RC109-216
Public aspects of medicine
RA1-1270
Subjects
Details
- Language :
- English
- ISSN :
- 2732494X
- Volume :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Antimicrobial Stewardship & Healthcare Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.84088830cb4477ebe3e07d894854b0c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1017/ash.2024.89