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Sympathetic improvement of cancer vaccine efficacy
- Source :
- Human Vaccines & Immunotherapeutics, Vol 16, Iss 8, Pp 1888-1890 (2020)
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis Group, 2020.
-
Abstract
- The link between stress, other psychological factors and response to cancer, or even the cancer incidence and metastasis, is well established. The inhibition of β-Adrenergic receptors (β-AR) using β-blockers was demonstrated to have an inhibitory effect on cancer recurrence. Direct effects on the stress-induced suppression of anti-tumor immune responses were also shown. In a recent issue of Cancer Immunology Research, Daher and colleagues studied the molecular mechanism behind this protective effect in the context of cancer vaccination. They provided evidence that the β-AR signaling affected the priming of naïve CD8 + T cells in their myeloma model, rather than effector CD8 + T cells which downregulated the expression of β-AR after activation and became insensitive to such signaling. Blocking the β-adrenergic signaling during vaccination led to increased expansion and effector functions of antigen-specific CD8 + T cells and reduced tumor growth. This has implications for the clinical use of β-blockers as adjuvants to enhance cancer vaccination and other types of immunotherapy.
Details
- Language :
- English
- ISSN :
- 21645515 and 2164554X
- Volume :
- 16
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- Human Vaccines & Immunotherapeutics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.83f4f9efa795409d85a6457baf6a0ffe
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/21645515.2019.1703456