Back to Search Start Over

Single-cell multiomics: a new frontier in drug research and development

Authors :
Jiaxiu Ma
Chao Dong
Aibin He
Haiqing Xiong
Source :
Frontiers in Drug Discovery, Vol 4 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Single-cell multiomics (sc-multiomics) is a burgeoning field that simultaneously integrates multiple layers of molecular information, enabling the characterization of dynamic cell states and activities in development and disease as well as treatment response. Studying drug actions and responses using sc-multiomics technologies has revolutionized our understanding of how small molecules intervene for specific cell types in cancer treatment and how they are linked with disease etiology and progression. Here, we summarize recent advances in sc-multiomics technologies that have been adapted and improved in drug research and development, with a focus on genome-wide examination of drug-chromatin engagement and the applications in drug response and the mechanisms of drug resistance. Furthermore, we discuss how state-of-the-art technologies can be taken forward to devise innovative personalized treatment modalities in biomedical research.

Details

Language :
English
ISSN :
26740338
Volume :
4
Database :
Directory of Open Access Journals
Journal :
Frontiers in Drug Discovery
Publication Type :
Academic Journal
Accession number :
edsdoj.83ca3cb2fcb04bb0bb8f5a669a44c3dd
Document Type :
article
Full Text :
https://doi.org/10.3389/fddsv.2024.1474331