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视网膜神经血管单元自噬:糖尿病视网膜病变的新视角

Authors :
Xiongyi Yang
Zexin Huang
Mei Xu
Yanxia Chen
Mingzhe Cao
Guoguo Yi
Min Fu
Source :
Journal of Diabetes, Vol 15, Iss 5, Pp 382-396 (2023)
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Abstract Diabetic retinopathy (DR) is one of the most prevalent retinal disorders worldwide, and it is a major cause of vision impairment in individuals of productive age. Research has demonstrated the significance of autophagy in DR, which is a critical intracellular homeostasis mechanism required for the destruction and recovery of cytoplasmic components. Autophagy maintains the physiological function of senescent and impaired organelles under stress situations, thereby regulating cell fate via various signals. As the retina's functional and fundamental unit, the retinal neurovascular unit (NVU) is critical in keeping the retinal environment's stability and supporting the needs of retinal metabolism. However, autophagy is essential for the normal NVU structure and function. We discuss the strong association between DR and autophagy in this review, as well as the many kinds of autophagy and its crucial physiological activities in the retina. By evaluating the pathological changes of retinal NVU in DR and the latest advancements in the molecular mechanisms of autophagy that may be involved in the pathophysiology of DR in NVU, we seek to propose new ideas and methods for the prevention and treatment of DR.

Details

Language :
English
ISSN :
17530407 and 17530393
Volume :
15
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Journal of Diabetes
Publication Type :
Academic Journal
Accession number :
edsdoj.83c9eac28283423aab95fc0f763a66c3
Document Type :
article
Full Text :
https://doi.org/10.1111/1753-0407.13373