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One-Year Effects of Omega-3 Treatment on Fatty Acids, Oxylipins, and Related Bioactive Lipids and Their Associations with Clinical Lipid and Inflammatory Biomarkers: Findings from a Substudy of the Vitamin D and Omega-3 Trial (VITAL)

Authors :
Olga V. Demler
Yanyan Liu
Heike Luttmann-Gibson
Jeramie D. Watrous
Kim A. Lagerborg
Hesam Dashti
Franco Giulianini
Mallory Heath
Carlos A. Camargo
William S. Harris
Jay G. Wohlgemuth
Allen M. Andres
Saumya Tivari
Tao Long
Mahan Najhawan
Khoi Dao
James G. Prentice
Julia A. Larsen
Olivia I. Okereke
Karen H. Costenbader
Julie E. Buring
JoAnn E. Manson
Susan Cheng
Mohit Jain
Samia Mora
Source :
Metabolites, Vol 10, Iss 11, p 431 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Omega-3 (n-3) treatment may lower cardiovascular risk, yet its effects on the circulating lipidome and relation to cardiovascular risk biomarkers are unclear. We hypothesized that n-3 treatment is associated with favorable changes in downstream fatty acids (FAs), oxylipins, bioactive lipids, clinical lipid and inflammatory biomarkers. We examined these VITAL200, a nested substudy of 200 subjects balanced on demographics and treatment and randomly selected from the Vitamin D and Omega-3 Trial (VITAL). VITAL is a randomized double-blind trial of 840 mg/d eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) vs. placebo among 25,871 individuals. Small polar bioactive lipid features, oxylipins and FAs from plasma and red blood cells were measured using three independent assaying techniques at baseline and one year. The Women’s Health Study (WHS) was used for replication with dietary n-3 intake. Randomized n-3 treatment led to changes in 143 FAs, oxylipins and bioactive lipids (False Discovery Rate (FDR) < 0.05 in VITAL200, validated (p-values < 0.05)) in WHS with increases in 95 including EPA, DHA, n-3 docosapentaenoic acid (DPA-n3), and decreases in 48 including DPA-n6, dihomo gamma linolenic (DGLA), adrenic and arachidonic acids. N-3 related changes in the bioactive lipidome were heterogeneously associated with changes in clinical lipid and inflammatory biomarkers. N-3 treatment significantly modulates the bioactive lipidome, which may contribute to its clinical benefits.

Details

Language :
English
ISSN :
22181989
Volume :
10
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Metabolites
Publication Type :
Academic Journal
Accession number :
edsdoj.83c39b76471a4147acd90b85adca4e35
Document Type :
article
Full Text :
https://doi.org/10.3390/metabo10110431