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Mortality and Severity of Coronavirus Disease 2019 in Patients with Long-Term Glucocorticoid Therapy: A Korean Nationwide Cohort Study

Authors :
Eu Jeong Ku
Keeho Song
Kyoung Min Kim
Gi Hyeon Seo
Soon Jib Yoo
Source :
Endocrinology and Metabolism, Vol 38, Iss 2, Pp 253-259 (2023)
Publication Year :
2023
Publisher :
Korean Endocrine Society, 2023.

Abstract

Background The severity of coronavirus disease 2019 (COVID-19) among patients with long-term glucocorticoid treatment (LTGT) has not been established. We aimed to evaluate the association between LTGT and COVID-19 prognosis. Methods A Korean nationwide cohort database of COVID-19 patients between January 2019 and September 2021 was used. LTGT was defined as exposure to at least 150 mg of prednisolone (≥5 mg/day and ≥30 days) or equivalent glucocorticoids 180 days before COVID-19 infection. The outcome measurements were mortality, hospitalization, intensive care unit (ICU) admission, length of stay, and mechanical ventilation. Results Among confirmed patients with COVID-19, the LTGT group (n=12,794) was older and had a higher proportion of comorbidities than the control (n=359,013). The LTGT group showed higher in-hospital, 30-day, and 90-day mortality rates than the control (14.0% vs. 2.3%, 5.9% vs. 1.1%, and 9.9% vs. 1.8%, respectively; all P

Details

Language :
English, Korean
ISSN :
2093596X and 20935978
Volume :
38
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Endocrinology and Metabolism
Publication Type :
Academic Journal
Accession number :
edsdoj.83abbfae2e2148aa8244f697d829d11f
Document Type :
article
Full Text :
https://doi.org/10.3803/EnM.2022.1607