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Mortality and Severity of Coronavirus Disease 2019 in Patients with Long-Term Glucocorticoid Therapy: A Korean Nationwide Cohort Study
- Source :
- Endocrinology and Metabolism, Vol 38, Iss 2, Pp 253-259 (2023)
- Publication Year :
- 2023
- Publisher :
- Korean Endocrine Society, 2023.
-
Abstract
- Background The severity of coronavirus disease 2019 (COVID-19) among patients with long-term glucocorticoid treatment (LTGT) has not been established. We aimed to evaluate the association between LTGT and COVID-19 prognosis. Methods A Korean nationwide cohort database of COVID-19 patients between January 2019 and September 2021 was used. LTGT was defined as exposure to at least 150 mg of prednisolone (≥5 mg/day and ≥30 days) or equivalent glucocorticoids 180 days before COVID-19 infection. The outcome measurements were mortality, hospitalization, intensive care unit (ICU) admission, length of stay, and mechanical ventilation. Results Among confirmed patients with COVID-19, the LTGT group (n=12,794) was older and had a higher proportion of comorbidities than the control (n=359,013). The LTGT group showed higher in-hospital, 30-day, and 90-day mortality rates than the control (14.0% vs. 2.3%, 5.9% vs. 1.1%, and 9.9% vs. 1.8%, respectively; all P
Details
- Language :
- English, Korean
- ISSN :
- 2093596X and 20935978
- Volume :
- 38
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Endocrinology and Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.83abbfae2e2148aa8244f697d829d11f
- Document Type :
- article
- Full Text :
- https://doi.org/10.3803/EnM.2022.1607