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RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling

Authors :
Haixia Zhu
Zongzhuang Wen
Aizhen Zhang
Dongyue Liu
Hongxiang Wang
Yin Cheng
Xing Yang
Yu Xiao
Jianyuan Li
Daqing Sun
Bin Wu
Jiangang Gao
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

RhoGDIα knockout mice show low male fertility and compromised spermatogenesis, with an underlying defect in F-actin cytoskeleton depolymerisation, which can be alleviated by inhibiting Rac1.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.8367a9c954974971a42ba2daaf6e8cdc
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04579-7