Atezolizumab Treatment for Progressive Multifocal Leukoencephalopathy

Authors :: Nicolas Lambert
Solène Dauby
Dominique Dive
Bernard Sadzot
Pierre Maquet
Source :: Emerging Infectious Diseases, Vol 28, Iss 1, Pp 253-256 (2022)
Publication Year :: 2022
Publisher :: Centers for Disease Control and Prevention, 2022.
Abstract: Atezolizumab successfully reinvigorated JC virus immunity in a patient in Belgium with progressive multifocal leukoencephalopathy, as demonstrated by clinical, virologic, and radiologic response to treatment. However, the treatment also resulted in immune reconstitution inflammatory syndrome and life-threatening immune-related adverse events. These conditions were treated with corticosteroids, leading to treatment resistance.