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Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage

Authors :
Maria Giulia Abate
Lorenza Moretto
Ilaria Licari
Teresa Esposito
Lorenzo Capuano
Carlo Olivieri
Arnaldo Benech
Matteo Brucoli
Gian Carlo Avanzi
Gianmaria Cammarota
Umberto Dianzani
Nausicaa Clemente
Gabriele Panzarasa
Giuseppe Citerio
Fabio Carfagna
Giuseppe Cappellano
Francesco Della Corte
Rosanna Vaschetto
Source :
Cells, Vol 8, Iss 7, p 695 (2019)
Publication Year :
2019
Publisher :
MDPI AG, 2019.

Abstract

Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. In SAH patients, plasma osteopontin (OPN) has been shown to independently predict poor outcome. The aim of the study is to investigate, in a selected population with severe SAH, OPN time course in cerebrospinal fluid (CSF) and plasma during the first week after aneurism rupture, and OPN prognostic value. We included 44 patients with the following criteria: (1) age 18 and 80 years, (2) diagnosis of SAH from cerebral aneurysm rupture, (3) insertion of external ventricular drain. Plasma and CSF were sampled at day 1, 4, and 8. OPN levels, in CSF and plasma, displayed a weak correlation on day 1 and were higher, in CSF, in all time points. Only in poor prognosis patients, OPN levels in CSF significantly increased at day 4 and day 8. Plasma OPN at day 1 and 4 was predictor of poor outcome. In conclusion, plasma and CSF OPN displays a weak correlation, on day 1. The higher levels of OPN found in the CSF compared to plasma, suggest OPN production within the CNS after SAH. Furthermore, plasma OPN, at day 1 and 4, seems to be an independent predictor of poor outcome.

Details

Language :
English
ISSN :
20734409
Volume :
8
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.831d7a2fe7ec4dcc845d8d527f872f1e
Document Type :
article
Full Text :
https://doi.org/10.3390/cells8070695