Candidate Plasma Biomarkers to Detect Anthracycline‐Related Cardiomyopathy in Childhood Cancer Survivors: A Case Control Study in the Dutch Childhood Cancer Survivor Study

Authors :: Jan M. Leerink
Elizabeth A. M. Feijen
Perry D. Moerland
Esmee C. de Baat
Remy Merkx
Helena J. H. van der Pal
Wim J. E. Tissing
Marloes Louwerens
Marry M. van den Heuvel‐Eibrink
A. Birgitta Versluys
Folkert W. Asselbergs
Arjan Sammani
Arco J. Teske
Elvira C. van Dalen
Margriet van der Heiden‐van der Loo
Eline van Dulmen‐den Broeder
Andrica C. H. de Vries
Livia Kapusta
Jacqueline Loonen
Yigal M. Pinto
Leontien C. M. Kremer
Annelies M. C. Mavinkurve‐Groothuis
Wouter E. M. Kok
Source :: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 14 (2022)
Publication Year :: 2022
Publisher :: Wiley, 2022.
Abstract: Background Plasma biomarkers may aid in the detection of anthracycline‐related cardiomyopathy (ACMP). However, the currently available biomarkers have limited diagnostic value in long‐term childhood cancer survivors. This study sought to identify diagnostic plasma biomarkers for ACMP in childhood cancer survivors. Methods and Results We measured 275 plasma proteins in 28 ACMP cases with left ventricular ejection fraction

Subjects :: anthracycline‐related cardiomyopathy
biomarkers
cancer therapy–related cardiac dysfunction
cardio‐oncology
chemokine ligands
childhood cancer survivors
Diseases of the circulatory (Cardiovascular) system
RC666-701

Language :: English
ISSN :: 20479980
Volume :: 11
Issue :: 14
Database :: Directory of Open Access Journals
Journal :: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Publication Type :: Academic Journal
Accession number :: edsdoj.82e6291c6713455590d77cad399df447
Document Type :: article
Full Text :: https://doi.org/10.1161/JAHA.121.025935

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