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Apremilast treatment of plaque psoriasis (PsO) after systemic therapy in Spanish clinical practice: Data from the APPROPRIATE study

Authors :
Pablo de laCueva
Susana Armesto
Encarnacion Montesinos
Francisco Javier García
Ana Maria Morales
Raquel Rivera‐Díaz
Mercedes Hospital
Jordi Mollet
Mar Llamas‐Velasco
Jose‐Manuel Carrascosa
Mercedes García
Jimena Vázquez
Lluís Puig
Source :
JEADV Clinical Practice, Vol 2, Iss 3, Pp 488-501 (2023)
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Abstract Background Despite the proven efficacy and safety of apremilast to treat plaque psoriasis (PsO), data regarding its real‐world use and patient‐perceived benefits are limited. Objectives Describe apremilast use, persistence and tolerability, and its patient‐perceived benefits and effectiveness in patients with PsO in Spanish clinical practice. Methods Observational, prospective, multicenter study including patients with moderate‐to‐severe PsO initiating apremilast 3 months (±4 weeks) before enrolment, after at least one conventional systemic therapy and no biologics. Prospective data were collected 3 (at enrolment), 6 and 12 months (±4 weeks) after apremilast initiation. Primary outcome was a Patient Benefit Index (PBI) score ≥1 (minimum clinically relevant benefit) at 6 months. Results Of 153 patients enroled, 119 were included in the analysis; mean (standard deviation [SD]) age, 52.8 (15.2) years. At apremilast initiation, mean (SD) Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) were 8.3 (4.9) and 10.5 (6.8), respectively. Most patients (81%) had comorbidities; PsO manifestations included scalp (47% of patients), palmoplantar (26%), nails (24%) and genitals (11%). Over three‐quarters (86%) of patients were continuing apremilast at Month 6, with most (91%) achieving a PBI ≥ 1% and 43% achieving a PBI ≥ 3; two‐thirds (68%) were continuing apremilast at Month 12, with 91% and 42% achieving a PBI ≥ 1 and ≥3, respectively. Mean (SD) pruritus scores decreased from 54.5 (32.1) at apremilast initiation to 23.4 (27.0) at Month 12; 57%, 69% and 69% of patients achieved a DLQI 0‒1, PASI

Details

Language :
English
ISSN :
27686566
Volume :
2
Issue :
3
Database :
Directory of Open Access Journals
Journal :
JEADV Clinical Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.828610197749e49fb5192e7531b1f0
Document Type :
article
Full Text :
https://doi.org/10.1002/jvc2.155