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Surveillance of COVID-19 vaccines: A comprehensive analysis of the first immunization drive in Ecuador

Authors :
Andrea Orellana-Manzano
Andrea C. Garcia-Angulo
Fernanda B. Cordeiro
Diana Carvajal-Aldaz
Elizabeth Centeno
María J. Vizcaíno
Sebastián Poveda
Merly Garcia
Carmen Matías-De la Cruz
Derly Andrade-Molina
Mariuxi Mirabá
Saurabh Mehta
Washington B. Cárdenas
Source :
Heliyon, Vol 10, Iss 6, Pp e27464- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

The initial phase of the COVID-19 vaccination in Ecuador occurred between April and November 2021. Initially, it focused on priority populations, including health professionals and other front-line workers. During this period, there was limited knowledge about the vaccine's adverse effects. A non-probability, observational study was conducted among university staff in Guayaquil, Ecuador, who received the AstraZeneca vaccine (n = 423) between April and November 2021. This study aimed to compare the acute adverse reactions by doses and to report the incidence of long-term adverse reactions within the AstraZeneca group. As a result, comparing acute adverse reactions between doses, the odds ratio for local pain, headache, muscle pain, fever, and chills are statistically higher after the first dose than the second dose. Survival curves indicated these symptoms appeared mainly within the first 6 h post-vaccination. This is the first pharmacovigilance study from Ecuador that analyzes survival probabilities for the AstraZeneca vaccine's adverse effects.

Details

Language :
English
ISSN :
24058440
Volume :
10
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.825f463c26341089ffd85dc13097dfa
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e27464