Hypocholesterolemic activity of 17α-methyl-5α-androstane-3β,17β-diol, a metabolite of 17α-methyltestosterone

The hypocholesterolemic activities of 17amethyltestosterone and its major identified fecal metabolite, 17α-methyl-5α-androstane-3β,17β-diol, were compared in dogs. The dose-response curves indicated that the two compounds had similar effects, although at doses below 1 mg/kg per day the diol appeared to be more active than the parent compound.