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Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland

Authors :
Kwok T’ng Chang
Dineen Robert A.
Whitehouse William
Lynn Richard M.
McSweeney Niamh
Sharkey Don
Source :
Open Medicine, Vol 17, Iss 1, Pp 1417-1424 (2022)
Publication Year :
2022
Publisher :
De Gruyter, 2022.

Abstract

Neonatal stroke is a devastating condition that causes brain injury in babies and often leads to lifelong neurological impairment. Recent prospective population studies of neonatal stroke are lacking. Neonatal strokes are different from those in older children and adults. A better understanding of its aetiology, current management, and outcomes could reduce the burden of this rare condition. The study aims to explore the incidence and 2 year outcomes of neonatal stroke across an entire population in the UK and Republic of Ireland. This is an active national surveillance study using a purpose-built integrated case notification-data collection online platform. Over a 13 month period, with a potential 6 month extension, clinicians will notify neonatal stroke cases presenting in the first 90 days of life electronically via the online platform monthly. Clinicians will complete a primary questionnaire via the platform detailing clinical information, including neuroimaging, for analysis and classification. An outcome questionnaire will be sent at 2 years of age via the platform. Appropriate ethics and regulatory approvals have been received. The neonatal stroke study represents the first multinational population surveillance study delivered via a purpose-built integrated case notification-data collection online platform and data safe haven, overcoming the challenges of setting up the study.

Details

Language :
English
ISSN :
23915463
Volume :
17
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Open Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.8248d10a52404d0d805606cc684ae915
Document Type :
article
Full Text :
https://doi.org/10.1515/med-2022-0554