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MMAB promotes negative feedback control of cholesterol homeostasis
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and cholesterol biosynthesis.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.822cd3ae48234a3c882c3e30c74ffa1c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-26787-7