The morphological changes of the aeroheamatic barrier of the respiratory portion of lungs at chronic hepatic insufficiency.

The purpose of the work was to determine the consequence of pathomorphological changes of the respiratory part and surfactant system of lungs at hepatic insufficiency, and also to estimate the dynamics of changes of both compensate and decompensate types in experimental model. 88 mature rats both sexes for modeling of the hepatic insufficiency by the Саmегоn’s method were used. Rat lungs were examined in 2, 4, 8 and 16 weeks after beginning of experiment. The increase of the volume of regions with emphysema, dysthelectasis and athelectasis at in the respiratory portion of the lungs were found. The increase of interstitial components with decreasing of relative thickness of epithelial layer of alveoli and the endothelial cells in capillaries were observed in aero-hematic barrier. The increase of vessel permeability, formation of hemorrhages, dysthelectasis and athelectasis are observed in the respiratory portion at chronic hepatic insufficiency. The sclerotic changes in the interalveolar septa with pneumofibrosis are determined in the terminal stages of chronic endotoxicosis.