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Targeting NTCP for liver disease treatment: A promising strategy
- Source :
- Journal of Pharmaceutical Analysis, Vol 14, Iss 9, Pp 100979- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- The sodium taurocholate co-transporting polypeptide (NTCP), a bile acids transporter, has been identified as a new therapeutic target for the treatment of liver disease. This paper thoroughly investigates the function of NTCP for regulating bile acid regulation, its correlation with hepatitis B and D infections, and its association with various liver diseases. Additionally, in this review we examine recent breakthroughs in creating NTCP inhibitors and their prospective applications in liver disease treatment. While this review emphasizes the promising potential of targeting NTCP, it concurrently underscores the need for broader and more detailed research to fully understand the long-term implications and potential side effects associated with NTCP inhibition.
Details
- Language :
- English
- ISSN :
- 20951779
- Volume :
- 14
- Issue :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Pharmaceutical Analysis
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.81c3b0a18a2c4951be68ecb1bcfd3a0f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jpha.2024.100979