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Objective Sleep Function is Associated with Hippocampal Subfield Volumes in Community-Dwelling Adults
- Source :
- Journal of Integrative Neuroscience, Vol 23, Iss 8, p 159 (2024)
- Publication Year :
- 2024
- Publisher :
- IMR Press, 2024.
-
Abstract
- Background: Sleep patterns often shift as people age, a phenomenon frequently associated with the onset of neurodegenerative conditions. Additionally, distinct alterations occur in brain structure as individuals grow older, particularly within the hippocampus, a region known for its role in cognition and sleep regulation. Yet, how exactly do changes in sleep relate to specific subfields within the hippocampus is still unclear. Methods: We conducted a study involving non-demented healthy adults from the Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION) cohort. Participants underwent objective sleep measurements using wrist Actiwatch and WatchPAT devices. Further, all participants underwent the same Magnetic Resonance Imaging (MRI) protocol, including a 3D high resolution T1-weighted sequence, on the same 3.0 Tesla MRI scanner using an eight-channel head coil. The study aimed to examine the relationship between objectively measured sleep metrics and the morphology of twenty-two distinct hippocampal subregions. Results: In total, 75 non-demented participants with 63 mean years of age were included in the study. Results indicated that a higher frequency of awakenings during sleep was associated with increased volume in the right presubiculum body (beta = 0.630, p False Discovery Rate (FDR)
Details
- Language :
- English
- ISSN :
- 02196352
- Volume :
- 23
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Integrative Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.81ae8b6e5e694e30abdd859ed54d4534
- Document Type :
- article
- Full Text :
- https://doi.org/10.31083/j.jin2308159