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Objective Sleep Function is Associated with Hippocampal Subfield Volumes in Community-Dwelling Adults

Authors :
Niki Mourtzi
Angeliki Tsapanou
Renia Morfakidou
Georgia Angelopoulou
Vasilios Constantinides
Eva Ntanasi
Eirini Mamalaki
Mary Yannakoulia
Efstratios Karavasilis
Foteini Christidi
Georgios Velonakis
Nikolaos Scarmeas
Source :
Journal of Integrative Neuroscience, Vol 23, Iss 8, p 159 (2024)
Publication Year :
2024
Publisher :
IMR Press, 2024.

Abstract

Background: Sleep patterns often shift as people age, a phenomenon frequently associated with the onset of neurodegenerative conditions. Additionally, distinct alterations occur in brain structure as individuals grow older, particularly within the hippocampus, a region known for its role in cognition and sleep regulation. Yet, how exactly do changes in sleep relate to specific subfields within the hippocampus is still unclear. Methods: We conducted a study involving non-demented healthy adults from the Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION) cohort. Participants underwent objective sleep measurements using wrist Actiwatch and WatchPAT devices. Further, all participants underwent the same Magnetic Resonance Imaging (MRI) protocol, including a 3D high resolution T1-weighted sequence, on the same 3.0 Tesla MRI scanner using an eight-channel head coil. The study aimed to examine the relationship between objectively measured sleep metrics and the morphology of twenty-two distinct hippocampal subregions. Results: In total, 75 non-demented participants with 63 mean years of age were included in the study. Results indicated that a higher frequency of awakenings during sleep was associated with increased volume in the right presubiculum body (beta = 0.630, p False Discovery Rate (FDR)

Details

Language :
English
ISSN :
02196352
Volume :
23
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Journal of Integrative Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.81ae8b6e5e694e30abdd859ed54d4534
Document Type :
article
Full Text :
https://doi.org/10.31083/j.jin2308159