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Gene duplication and subsequent diversification strongly affect phenotypic evolvability and robustness
- Source :
- Royal Society Open Science, Vol 8, Iss 6 (2021)
- Publication Year :
- 2021
- Publisher :
- The Royal Society, 2021.
-
Abstract
- We study the effects of non-determinism and gene duplication on the structure of genotype–phenotype (GP) maps by introducing a non-deterministic version of the Polyomino self-assembly model. This model has previously been used in a variety of contexts to model the assembly and evolution of protein quaternary structure. Firstly, we show the limit of the current deterministic paradigm which leads to built-in anti-correlation between evolvability and robustness at the genotypic level. We develop a set of metrics to measure structural properties of GP maps in a non-deterministic setting and use them to evaluate the effects of gene duplication and subsequent diversification. Our generalized versions of evolvability and robustness exhibit positive correlation for a subset of genotypes. This positive correlation is only possible because non-deterministic phenotypes can contribute to both robustness and evolvability. Secondly, we show that duplication increases robustness and reduces evolvability initially, but that the subsequent diversification that duplication enables has a stronger, inverse effect, greatly increasing evolvability and reducing robustness relative to their original values.
- Subjects :
- genotype–phenotype map
gene duplication
self-assembly
Polyomino
Science
Subjects
Details
- Language :
- English
- ISSN :
- 20545703
- Volume :
- 8
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Royal Society Open Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.816f11ebb33470484ea23ffe5def107
- Document Type :
- article
- Full Text :
- https://doi.org/10.1098/rsos.201636