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A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917

Authors :
Jean-Philippe Nougayrède
Camille V. Chagneau
Jean-Paul Motta
Nadège Bossuet-Greif
Marcy Belloy
Frédéric Taieb
Jean-Jacques Gratadoux
Muriel Thomas
Philippe Langella
Eric Oswald
Source :
mSphere, Vol 6, Iss 4 (2021)
Publication Year :
2021
Publisher :
American Society for Microbiology, 2021.

Abstract

Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal cancer.

Subjects

Subjects :
Microbiology
QR1-502

Details

Language :
English
ISSN :
23795042
Volume :
6
Issue :
4
Database :
Directory of Open Access Journals
Journal :
mSphere
Publication Type :
Academic Journal
Accession number :
edsdoj.816552cb3c9c46a58c2d718922be086d
Document Type :
article
Full Text :
https://doi.org/10.1128/mSphere.00624-21