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The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts
- Source :
- Animal Cells and Systems, Vol 22, Iss 5, Pp 299-304 (2018)
- Publication Year :
- 2018
- Publisher :
- Taylor & Francis Group, 2018.
-
Abstract
- MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2.
Details
- Language :
- English
- ISSN :
- 19768354 and 21512485
- Volume :
- 22
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Animal Cells and Systems
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.812b596a2193418d87ba6a969a2265ad
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/19768354.2018.1512520