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Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins

Authors :
Mehmet Kemal Tur
Adebukola K. Daramola
Stefan Gattenlöhner
Marco Herling
Shivan Chetty
Stefan Barth
Source :
Biomedicines, Vol 5, Iss 4, p 59 (2017)
Publication Year :
2017
Publisher :
MDPI AG, 2017.

Abstract

Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of cellular process and have been identified as positive mediators of apoptosis via extrinsic and intrinsic death-regulating signaling pathways. Tumor suppressor activities have been shown for DAPk1 and DAPk2 and they are downregulated in e.g., Hodgkin’s (HL) and B cell lymphoma (CLL), respectively. Here, we review a targeted therapeutic approach which involves reconstitution of DAPks by the generation of immunokinase fusion proteins. These recombinant proteins consist of a disease-specific ligand fused to a modified version of DAPk1 or DAPk2. HL was targeted via CD30 and B-CLL via CD22 cell surface antigens.

Details

Language :
English
ISSN :
22279059
Volume :
5
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.81239a63d3d4979ae3dade26808e59b
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines5040059